Assessment Of Antiarthritic Potential Of Carica Papaya L. Leaves Extract And Fractions: Histopathological Analysis

Carica papaya L has been traditionally claimed for curing inflammation hence the present work exemplifies anti-arthritic potential of crude leaves extract and its fractions in arthritic models. Screening on this plant established presence kaempferol which might possess antiarthritic properties. Kaempferol was quantitatively estimated by high performance thin layer chromatographic method chloroform fraction found to be 0.08% w/w. Arthritis induced intraplantar administration considering formaldehyde (2%v/v), turpentine oil emulsion (10%v/v) complete Freund’s adjuvant (1%v/v) left hind paw rats. Paw oedema, body weight, haematological parameters, level serum enzyme markers, biochemical interleukin-6 histopathological analysis were observed all groups. Present experimental justifies that chronic arthritis, iinvolvement is associated with non-articular manifestations joint including anaemia. The dose dependent effect acute model ameliorating biomarkers, weight abnormalities, interleukin-6. explanation L. revealed potential.